Fallowing existence selected away from high (& turning down the scholarship to Clemson) in the first around of the 2002 draft, he spent spent the wintertime of 2002-2003 in the Puerto Rican League. Subsequently, he played for the Wilmington Blue Rocks and Wichita Wranglers, where he was known as a Royals Minor League Pitcher of the season, & The Sporting News Minor League Player of the Month, sustaining the 15-Four record & Ace.93 ERA. Greinke mass produced his major-league debut in May 22, 2004 against the Oakland Athletics.

He ended the 2004 year by having a record of Ogdoad wins & Eleven losses (2nd-greatest on the team, when Jimmy Gobble) and the Ternary.97 ERA. Greinke has been in comparison first Hall of Famer Greg Maddux and Royals great Bret Saberhagen. He has sports endorsement deals using Adidas and Rawlings.

Dig in the U.s. League, Greinke seldom loony due to the designated hitter rule. Greinke's 1st major league hit was the personal process off Arizona Diamondbacks pitcher Russ Ortiz in a 12-11 loss in June 10, 2005.